SummaryAlthough descriptions of quality of life and patient reports of mood in sickle cell disease (SCD) have become more common in the literature, less is known about psychiatric illness prevalence, presentation, and treatment, particularly for adults. We provide a narrative review of what is known about common and debilitating psychiatric conditions such as depression, anxiety, and cognitive impairment, specifically for adults with SCD. We discuss the limitations of the current evidence, make provisional recommendations, and identify opportunities for research and improved care.

Conflict of interest: No COI declared COI notes: Preprint server: No; Author contributions and disclosures: ADM designed the research and wrote the paper SGC managed the data and did the analysis AH participated in background research and writing the paper EJL did data collection SMD did data collection MYM participated in data analysis, interpretation, and writing the paper Non-author contributions and disclosures: No;