No abstract

No abstract

Twenty-one patients with primary humoral immunodeficiency were treated for 1 year with a chemically intact immunoglobulin, 300 mg/kg body weight given intravenously every 3 weeks, to compare immunoglobulin levels and clinical status with results achieved after standard treatment with intramuscular immunoglobulin given previously for 1 year. A substantial reduction of specific acute illnesses and antibiotic use was found for 18 of the 21 patients, particularly during the second 6 months of treatment. Average IgG levels before intravenous infusion were increased 243 mg/dL over previous intramuscular pre-injection levels. Adverse effects were recorded for 2.5% of infusions.

Rlonocyte and polynlorphonuclcar neutrophil (I'hlN) chemotaxis was studied in cord blood fro111 healthy terrn infants. Rlonocytc chemotaxis was nor~llal to increased ( 1 15-12670) whereas PRlN che~~lotaxis was clecreasecl (79%) in comp:lrison with that of healthy atlult control subjects. Generation of chenlotactic factors fro111 cord sera was inlpairecl, being 55% of that generated by pooletl nornlal hunlan serulll (I'NIIS). Cord serunl was less inhibitory than poolecl adult hurilan scrtrni for adult tilonocytes when the cells were suspentled in 1070 serulli and testetl for chcn~otaxis. No inhibition of cherllotactic factors by either corcl or adult sera was observed. 'l'hc dissociation of cherllotactic response of the two tlifferent phagocytic cells may represent a protective ~ilecllanisril whereby one cell can corllpensatc for a clefect in the response o f the othcr.