Ontario *co-first authorship for equal contribution 4. Authors contributions: FH designed experiments, helped in test experiments, analyzed data, and edited the manuscript. MG performed experiments, analyzed data, prepared the figures, and wrote the first draft of the manuscript. CO performed the surgeries, helped in test experiments, performed perfusion and brain extraction and edited the manuscript. ED performed part of the experiments and data analysis. KJ edited the manuscript. SE designed experiments, edited the manuscript, and approved the final version of the manuscript. SS designed experiments, edited the manuscript, and approved the final version of the manuscript.

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