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This study presents empirical findings about the association between childhood neglect and adolescents' subsequent involvement with drug and alcohol related offense from a sample of 251 neglected children and their community matched control (N = 502) from a 17-year period longitudinal data set. Findings confirmed that neglected children were at greater risk to be arrested for later juvenile drug and alcohol offenses than non-neglected children. Being male, White and the presence of domestic violence also significantly contributed to elevated risks of being arrested for juvenile drug and alcohol violations for neglected children. Implications for practice and future research are discussed.