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Indonesian Tropical Fruit Research Institute (ITFRI) is one of the research institutes under the Indonesian Agency for Agricultural Research and Development (IAARD), Ministry of Agriculture. The responsibility of ITFRI is to produce technologies for increasing competitiveness of tropical fruit agribusiness in the global market. The priority commodities handled are divided into main and potential commodities. The main commodities are banana, mango, mangosteen, and durian, while the potential commodities are papaya, snake fruit, watermelon, Cucumis melo, pineapple, and breadfruit. Research activities of ITFRI could be divided into three groups namely fruits breeding and genetic resources, ecophysiology, and plant protection. This paper will explain the role of ITFRI to support food security through fruit research and development activities.