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1 Allopurinol usage in 50 patients of a city teaching hospital was surveyed. 2 The plasma concentrations of oxipurinol and uric acid and the urinary production of uric acid were examined. 3 The daily doses of allopurinol ranged from 50 to 1200 mg but 83% of patients were taking 300 mg daily. 4 A wide range of plasma oxipurinol concentrations was observed from 2.8 to 55.8mg 11 with a mean ± s.d. of 15.2 ± 11.7 mg l-1. 5 The population studied included a high proportion of patients with renal impairment and creatinine clearance was a significant determinant of oxipurinol concentrations (P < 0.005). 6 There was no significant correlation between plasma urate and plasma oxipurinol concentrations and only a few plasma urates were above the upper limit of the reference range of the laboratory. 7 It was apparent that many patients were taking unnecessarily high daily doses of allopurinol and that renal status was not always considered when deciding dosage regimens of allopurinol.

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