Özet: Apiterapi, Latince arı anlamına gelen apis kelimesinden türetilmiş bir kelimedir. Apiterapi uygulaması yüzlerce yıl önceye dayanmaktadır. Antik Mısır ve Çin'de hekimlerin günümüzden 4 bin yıl önce bazı arı ürünlerini kullandıklarını gösteren belgeler bulunmaktadır. Apiterapi, sağlığın korunması ve hastalıkların tedavisinde etkili bir yöntem olarak kullanılmaktadır. Bu yöntemde kullanılan başlıca ürünler, bal, apilarnil, propolis, arı sütü ve pergadır. Apiterapide kullanılan bu ürünlerin genellikle antibakteriyel, antioksidan, antiinflamatuar, vazodilatif ve antitümör etki gibi çok önemli etkilere sahip olduğu bilinmektedir. Olumlu etkilerinin yanı sıra apiterapi ürünlerinin bazılarının kullanımının allerjik reaksiyona sebep olabileceği de çalışmalarda gösterilmiştir. Sonuç olarak güvenilir kaynaklardan elde edilen bu besin maddelerinin kullanımının sağlık üzerine yararlı etkileri bulunmaktadır.
Xylooligosaccharides (XOS) are the oligomers of β-1,4 linked xylose monomers and they have health promoting effect by modulating the beneficial microorganisms in intestine. In this study, hydrolysate obtained from hemp (Cannabis sativa) shives was investigated in terms of its in vitro toxicological impacts at cellular and genetic levels and antioxidant activity. The hydrolysate was found to contain 0.264 mg mL-1 of xylose, 0.789 mg mL-1 of xylobiose and 0.171 mg mL-1 of xylotriose in addition to hydroxymethlyfurfural (HMF) and furfural (F) at concentrations of 0.545 mg mL-1 and 0.107 mg mL-1, respectively. The cells, colon epithelial cells (CoN) and colon cancer cells (Caco-2), exposed to 5.00 mg mL-1 or lower XOS hydrolysate showed very similar growth profiles to the untreated control cells. At the genetic level, the oxidative responses of the cell types to XOS hydrolysate were different as measured by NFE2L2 (Nuclear factor, erythroid-derived 2-like 2) gene expression. Regarding antioxidant activity, the amount of XOS hydrolysate (IC50) that cleared 50 % of the 2,2-diphenyl-l-picrylhydrazyl (DPPH) in the medium was calculated as 0.12 mg mL-1. To conclude, based on in vitro studies, XOS hydrolysate obtained from lignocellulosic hemp shives emerges as an innovative, alternative and safe functional food candidate.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.