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Anahtar KelimelerHelikobakter Pilori; Tonsillektomi; Tonsil; Tonsillit; Giemsa Abstract Aim: Helicobacter pylori is the major gastric pathogen which has an important role in the etiopathogenesis of chronic gastritis. We investigated the presence of Helicobacter pylori as an extragastric reservoir in the tonsillectomy specimens to display if it is an etiologic factor in the development of chronic tonsilitis. Material and Method: In the current study, 100 cases with chronic tonsilitis were examined in bilateral tonsillectomy specimens. The colonization of the microorganism have been evaluated with hematoxylineosin and giemsa stains under the light microscope.Results: Helicobacter pylori has been detected in 33 cases (33%) on one side of the bilateral tonsillectomy specimens while it has been seen in 15 cases (15%) on both sides which demonstrated positivity in 48 cases (48%) in total. No colonization has been observed in the remaining 52 cases (52%). Discussion: Due to the considerable positivity in our study, the histopathologic evaluation of tonsillary Helicobacter pylori colonization may be instrumental in the etiologic association with chronic tonsillitis.

Objective: angiosarcomas and hemangioendotheliomas are rare malignant vascular neoplasms (MVTs). Here, we reviewed the clinicomorphological characteristics of 27 MVTs with the implementation of two novel immunohistochemical markers: GLUT1, and FKBP12.Material and Method: MVTs, except for Kaposi's sarcoma, were retrieved from the archive and reviewed. Tumor size, the presence of hemorrhage and necrosis, growth pattern, cellularity, cellular characteristics and mitotic activity were recorded as morphological variables. immunohistochemically, CD34, CD31, GLUT1, FKBP12, Mdm2, p53, c-kit, and CD99 were applied. Clinical information was gathered from hospital records and computer-based patient data systems. Results:The median age was 53 years (range 16-77). Extremities (37%) were the most common primary site followed by the head and neck. Five of 16 (31%) low grade and 7 of 11 (64%) high grade tumors were metastasized to varying organs, mainly the liver and lungs. The median survival was 49 months. ninety percent of high grade tumors were larger than 3 cm. Hemorrhage and necrosis were seen in 85% and 41% of cases, respectively. nuclear pleomorphism, cellularity and mitotic activity were higher in high grade tumors than in low grade ones (p<0.0001). While 68% of the cases expressed CD34, 81% of them were positive with CD31. all cases except one low grade tumor were strongly and diffusely stained with FKBP12. Significant GLUT1 expression was observed in 23% of cases, especially in areas showing epithelioid morphology. Either Mdm2 or p53 was positive in over one third of the tumors. Conclusion:The studied markers were not able to distinguish between low and high grade MVTs. FKBP12 may take a role in the diagnostic panel of MVTs. GLUT1 expression, previously proposed for the diagnosis of infantile hemangioma, should be assessed carefully since almost one quarter of MVTs were also GLUT1 positive.

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