A new thiosemicarbazone ligand was synthesized and characterized using spectroscopic techniques (UV-Vis and IR) and synchrotron x-ray powder diffraction. With M2+ = Mn2+, Zn2+ and Cd2+, coordination compounds of the type (M[L]2) were isolated. In the presence of sodium dithiocarbamate salts (NadiEtdtc.3H2O = sodium diethyldithiocarbamate trihydrate and Napipdtc = sodium piperidinedithiocarbamate), Zn2+ and Cd2+ were able to form ternary octahedral complexes where each metal binds a deprotonated (thiosemicarbazone) ligand, a monobasic dithiocarbamate ligand and a water molecule. In vitro biological evaluation tests of the free HL ligand and its metal complexes against selected fungal and bacterial cultures were performed. Compared with HL, the complexes displayed enhanced biological activities and ternary Zn (II) complexes displayed comparable antibacterial activities to the chloramphenicol standard.

Graphical abstract Sets of 3-alkenyl-2-oxindoles were synthesized of potential antiproliferative (against PaCa-2 and MCF7cancer cell lines) and promising properties against SARS-CoV-2.

An anti-neoplastic fluoro-substituted dispiro-oxindole is described along with theoretical studies and single crystal X-ray analysis.

Key indicators: single-crystal X-ray study; T = 293 K; mean (C-C) = 0.003 Å; R factor = 0.062; wR factor = 0.154; data-to-parameter ratio = 17.0.In the title molecule, C 27 H 24 N 2 O 2 , the pyrrolidin-2-one ring is almost planar (r.m.s. deviation = 0.003 Å ), the pyrrolidine ring has an envelope conformation (the N atom is the flap atom) and the cyclopentanone ring is twisted about the C q -C m bond (q = quaternary and m = methylene). The ketone O atoms are directed to opposite sides of the molecule. Supramolecular chains along the a axis are formed in the crystal packing mediated by N-HÁ Á ÁN and C-HÁ Á ÁO interactions. These are connected into layers in the ab plane via C-HÁ Á Á interactions. Related literature