Benign Prostatic Hyperplasia (BPH) is the second most common urological disorder encountered in a urology clinic in Indonesia. This disease is commonly found in men over 50 years. one of the risk factors that are thought to influence the occurrence of BPH is diabetes mellitus (DM). The purpose of this study was to determine the relationship of BPH with DM type 2 in Rumah Sakit Dustira. An observational analytic study with cross sectional design conducted at Rumah Sakit Dustira in the 2018-2019. This study involved 19 people with DM and 19 people without DM by consecutive sampling. The research data was obtained from medical records. The results are majority of subjects were > 75 years (33.33%), the mean prostate volume of BPH patients who also had DM was 55 grams and those who did not have DM was 42.67 grams. The analysis showed that there was a significant difference between the prostate volume of BPH patients with type 2 diabetes mellitus and without type 2 diabetes mellitus (p <0.05). It is concluded that there is a significant difference between the prostate volume of BPH patients with type 2 diabetes mellitus and without type 2 diabetes mellitus.