VERA, W.; MORA, H.; LAYA, M. S.; BEDOYA, L.; CABRERA, E. V.; J. Sci. Ind. Res. 65 (2006) 4, 299-308; Cent. Quim., Inst. Venez. Invest. Cient., Caracas 1020-A, Venez.; Eng.) -Lindner 33-282

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This article reviews the isolation, biological activity and syntheses of several diterpenes. The chemistry and biological activities of norditerpene dilactones have been described. The aim of the present article is to provide an overview on the important role of diterpenoid compounds in medicine and agriculture. The synthetic discussions of these diterpenes are very briefly described. Dedicated to Professor Kenji Mori for his valuable contributions to Terpene Chemistry.COOH Me Me OH Me Me H The Chemistry of Bioactive Diterpenes

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The transformations of 5-methoxy, 6-methoxy and 7-methoxy-a-tetralones are described. Studies on the synthesis of diterpenes veadeiroic acid 12, triptolide 18, sesquiterpenes biflorin 25, mansonone F 26, cacalol 39 and a potential intermediate for 11-deoxydaunomycinone 59 from 5-methoxy-a-tetralone 1 are discussed. Several intermediates for diterpenoid compounds and a total synthesis of phytoalexin orchinol 53 from 6-methoxy-a-tetralone 2 have been accomplished. 7-Methoxy-a-tetralone 3 has proved to be a suitable starting material for a simple and short synthesis of cadinene dihydrochloride 45.