Antibiotik merupakan obat yang banyak dikenal masyarakat, namun penggunaan antibiotik sering kali tidak tepat, yang dapat berakibat pada peningkatan resistensi bakteri terhadap antibiotik. Resistensi merupakan kemampuan bakteri dalam menetralisir dan melemahkan daya kerja antibiotika. Pada awalnya resistensi terjadi ditingkat rumah sakit, tetapi lambat laun berkembang juga dilingkungan masyarakat, khususnya Streptococcus pneumonia (SP), Streptococcus Pneumonia, dan Esherichia coli (Menkes RI, 2016). Hasil penelitian tentan gambaran tingkat pengetahuan penggunaan obat golongan obat antibiotik di Desa KEBONHARJO Kecamatan PATEBONKabupaten Kendal diperoleh kesimpulan sebagai berikut, Tingkat pengetahuan di Desa KEBONHARJO Kecamatan PATEBONKabupaten Kendal dikatagorikan sedang. Hal ini dapat dilihat dari hasil tingkat pengetahuan yaitu tingkat pengetahuan tertinggi adalah 13 (18,1%) responden, tingkat pengetahuan sedang 38 (52,8%) responden dan tingkat pengetahuan terendah adalah 21 (29,2%) responden.

Diabetes Mellitus (DM) is a chronic condition that occurs because the body cannot produce insulin normally or insulin cannot work effectively. Indonesia is ranked fourth in the number of people with DM in the world after the United States, India and China. Rational use of drugs requires that patients receive treatment according to clinical needs, in  the required dose of each individual within a certain period of time at the lowest cost. This research is a descriptive research. Descriptive research method is a research method that is carried out with the main aim of making a picture or description of a situation objectively. Descriptive research methods are used to solve or answer the problems being faced in the current situation.  The profile of the use of antidiabetic drugs in terms of gender is mostly women with a percentage of 57.7%, most patients are in the 40-60 year age group as much as 50.0%. The most use of single antidiabetic drugs is sulfonylurea 33.6%, combination therapy mostly uses 3 classes of drugs by 63.6%, namely Alpha Glucoside Inhibitors, Sulfonylureas and Biguanides. For the administration of combination therapy, the most insulin is a combination of longrapid and85.7 actingacting %.

Prescribing antibiotics for infectious diseases that are quite high and less wise will increase the incidence of resistance. Research objectives to determine the influence of parental education level on the knowledge of antibiotic use in children aged 0-12 years in TanjungmojoVillage, Kangkung District, Kendal Regency. The study used observational analytics with a cross sectional approach. The population in this study was all parents who had children aged 0-12 years in TanjungmojoKidul Village. The sampling technique used is purposive sampling of 55 respondents who have met the criteria of inclusion and exclusion. Education level data and further knowledge levels analyzed with Chi-Square test. Chi-Square test results between education level and knowledge level obtained p = 0.006. This shows a p value of less than 0.05 with a confidence level of 95% so there is a significant relationship between the level of education and the level of knowledge about antibiotics. There is a relationship of parents' education level to knowledge about antibiotics in children aged 0-12 years in TanjungmojoVillage Kangkung district of Kendal regency.