(1) Serum nitric oxide (NO) production is increased in normal pregnancy than in the normal non-pregnancy. (2) Maternal and fetal serum NO levels are increased significantly in pre-eclampsia and eclampsia, which possibly represents a compensatory/protective mechanism to maintain blood flow and limit platelets aggregation in the fetal-maternal circulations. (3) The increase in NO production is directly related to the severity of pre-eclampsia; this would be of diagnostic significance for the prediction of the severity of this syndrome.

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INTRODUCTIONThe overactive bladder (OAB) is a highly prevalent disorder that impacts the lives of millions of people worldwide. Despite its high prevalence, many sufferers do not seek medical attention and are not aware that OAB is treatable.1 Micturation disorders are responsible for increased morbidity throughout the world. This morbidity ranges from worrisome symptoms to life-threatening renal failure. Disturbances in voiding may sign neurological, metabolic, inflammatory, or infectious diseases. Voiding dysfunction may also arise from injury, outlet obstruction, structure changes in the bladder and urethra or loss of their supporting structures with aging. 2Research on urinary storage problems has focused on incontinence in women, but during last years, other urinary storage problems (urgency, frequency, and nocturia) has commanded attention worldwide.3 The prevalence of OAB is variable ranging from 3% to 43%, depending on the population assessed and the definition used. 4 The prevalence of OAB increase with age because of neurological and musculoskeletal effects, degenerative ABSTRACT Background: The current study aims to estimate the prevalence of Overactive bladder (OAB) and urinary incontinence (UI) among women attending Assiut Woman's Health Hospital. Additionally, to explore the impact of UI and OAB on The Quality of Life (QOL) of women. Methods: A population-based survey included participants aged 18 years and older selected from Assiut Woman's Health Hospital and received The Bristol Female Lower Urinary Tract Symptoms Questionnaire (BFLUTSQ). OAB was defined in to two versions using the international continence society (ICS) definition of 2002 as either urgency sometimes or more alone (OAB1) or urgency sometimes or more with frequency more than eight times per day and /or nocturia once or more per night (OAB2). Incontinence and other LUTS were positive if answer scores ≥2 to BFLUTSQ question for incontinence and other LUTS. Results: The total prevalence of OAB was 39.0% (351 women). The prevalence of OAB dry and OAB wet was 26% (234 women) and 13% (117 women), respectively, which suggested that 66.7% suffer from OAB dry and 33.3% suffer from OAB wet. The prevalence of dry OAB is significantly higher than wet OAB. The overall prevalence of UI was 22.2% (201 women). The prevalence of stress UI, urge UI and mixed UI was 5.7%, 5.1% and 11.4%, respectively. Conclusions: OAB symptoms and UI are highly prevalent. Furthermore, both of them have severe effects on daily and sexual life as well as being related to psychological symptoms such as anxiety and depression.