Objective: The present study was conducted to investigate the effects of Artemisia extract on some immunological parameters in streptozotocin-induced diabetic mice. Methods: After preparation of Artemisia extract, many chemical tests were used to identify the type of element and compounds presented in this plant using many chemical techniques. Thirty five streptozocin (STZ) induced diabetes mice were divided in to 5 groups; the first group provided only with water, the other four groups were consumed orally ingested the plant extract in four different concentration (2000, 1000, 500,250) mg/Kg of body weight. Another 10 mice didn’t injected with STZ were divided in to two groups; one consumed Artemisia (Art group), and the second consumed only normal saline (Cont. group). After 14 days of diabetes induction and Artemisia extract treatment, the mice were sacrificed. Blood and tissue (brain, spleen and kidney) were collected. Fasting blood sugar and insulin levels were determine in the serum. Furthermore Tumor Necrosis Factor- alpha (TNF- α) and Interleukin-6 (IL-6) levels were determined in the serum and aliquots of homogenize tissues. Results: Results declared that the extract of Artemisia fruit contains high levels of active compounds especially antioxidant compounds. IL-6 and TNF-α levels were decreased while insulin and glucose levels were increased in the STZ- induce mice group. Artemisia extract effects differently on glucose and insulin levels depend on its concentration. Interestingly, IL-6 and TNF-α levels increase in serum, brain and spleen of the STZ-induce mice group consumed different concentration of Artemisia but it normalized in the STZ-induce mice group consumed 250 mg/kg Artemisia, as well as insulin and glucose levels for the same group, while there was no difference in kidney. Conclusion: Artemisia can control diabetes in 1000 and 500mg/Kg through controlling insulin level, and in the other hand, using the plant extract in 250mg/Kg ,acts as immune modulator for anti-inflammatory agents IL-6 and TNF-α.