SummaryAimsThis open‐label prospective phase I/IIa clinical study used autologous bone marrow‐derived mesenchymal stromal cells (BM‐MSCs) followed by mesenchymal stromal cells conditioned media (MSC‐CM) for the first time to treat multiple sclerosis (MS) patients. The primary goal was to assess the safety and feasibility and the secondary was efficacy. The correlation between the MSC‐CM content and treatment outcome was investigated.MethodsTen MS patients who failed conventional therapy were enrolled. Adverse events were recorded to assess safety. The Expanded Disability Status Scale (EDSS) was the primary efficacy measurement, the secondary included clinical (25WFT, 9‐PHT), cognitive (MMS), ophthalmology (OCT, VEP), and radiological (MRI lesion and volume) tests. The MSCs‐CM concentration of 27 inflammatory biomarkers was investigated.ResultsThe treatment protocol was well tolerated by patients. There was an overall trend of improvement in all the tests, except the lesion volume which increased significantly. A decrease of 4 and 3.5 points on the EDSS was achieved in two patients. We report a correlation between a decreased lesion number at baseline and higher IL‐6, IL‐8, and VEGF MSC‐CM content.ConclusionThe used protocol was safe and feasible with possible efficacy. The addition of MSC‐CM could be related to the magnitude of EDSS improvement observed.

Objectives:To estimate normal linear dimensions and volume of spleen in Jordanians using ultrasonography, and to correlate splenic volume with age and body parameters: height, weight, body surface area (BSA), and body mass index (BMI).Methods:A prospective pilot study was conducted on 205 volunteers (115 males and 90 females) not known to have any conditions likely to be associated with splenomegaly. The study was performed at the Radiology Department, Jordanian University Hospital, Amman, Jordan, between December 2013 and August 2014. All linear dimensions of spleen were measured, and splenic volume (index) was calculated using the standard prolate ellipsoid formula (length × width × depth × 0.523). The splenic volume was then analyzed with age and body parameters using the Pearson’s correlation coefficient.Results:The mean (± SD) splenic dimensions were 10.72±1.37 cm in length, 7.40±1.52 cm in width, 4.40±1.47 cm in depth, and 184.15±79.56 cm3 in volume. Men had larger spleens than women (p<0.0001). Age had no significant effect on spleen volume (r=0.11, p=0.12). There was a significant moderate positive correlation (p<0.0001), using Pearson’s correlation coefficient, between the spleen volume, and other parameters (height, weight, BSA, and BMI), with correlation coefficients exceeding 0.3.Conclusion:A local reference of spleen dimensions was established with a different range of values reported previously.

HighlightsUreterocele is a rare condition. One of its presentation is the presence of a stone, usually a solitary stone, inside the ureterocele.Ureteroceles represent a clinical challenge in term of diagnosis and management due to their variable presentations and types.Our patient ureterocele was complicated by a large calculus so we decided to proceed with endoscopic resection of the ureterocele along with stone removal.

HighlightsLeydig cell tumor is a testicular tumor with a low incidence accounting for 1–3% of testicular neoplasms.Only about 10% of them show malignant behavior in the form of metastatic disease.When diagnosed and treated early, long-term favorable outcomes are seen even with its potential metastatic behavior.

SummaryData of 17 male patients with a final diagnosis of transient osteoporosis (TO) of the hip seen at the radiology department of a university hospital over a period of 7 years were retrospectively studied. Comparison of the proportion of doctors among TO cases with that among other hip joint pathologies revealed a significant difference.PurposeThe objective of this study is to present clinical and radiological findings of hip TO and to assess the association of the condition with patients' occupation.Materials and methodsData of 17 male patients with a final diagnosis of transient osteoporosis of the hip seen at the radiology department of a university hospital over a period of 7 years were retrospectively studied.ResultsThe diagnosis of transient hip osteoporosis was in accordance with the published literature for clinical, imaging findings, and laboratory results. Among the 17 cases of male transient hip osteoporosis, 65% were physicians and 12% were commercial pilots. Comparison of the proportion of doctors among TO cases with that among other hip joint pathologies revealed a significant difference. Abnormal low hormone levels of testosterone and 25-cholicalciferol (vitamin D) were detected in three and two patients, respectively.ConclusionThe preponderance of physicians among patients with transient hip osteoporosis has not been previously reported. Etiological contribution of endocrine pathology and type of occupation to the causation of transient osteoporosis merits further research.