BackgroundDry eye is a serious public health issue that causes ocular discomfort, weariness, and visual disturbances that can disrupt everyday activities. Dry eye disease is one of the most common reasons people seek eye care. Therefore, this study aimed to assess the association between screen time, sleep quality, and dry eye among college students in Saudi Arabia. MethodsThis cross-sectional study was conducted among college students in Saudi Arabia. Data were collected through a validated questionnaire distributed via social media. ResultsA total of 1,593 participants were included. Many of them were aged between 18-25 years (80.7%) and females were (65.0%). Females and residents of the middle region had significantly more severe sleep-wake difficulties than other people (p<0.001). Participants with a master's degree had lower severe sleep-wake difficulties than other participants (p<0.001). Participants who spent between 4-6 hours on the screen showed high severe sleep-wake difficulties (p<0.001). Regarding eye dryness, females, participants with a bachelor's degree, and participants who spent more than six hours on screen had more severe symptoms of eye dryness. Nearly half of the participants with severe sleep-wake difficulties reported mild to moderate symptoms of dry eye (p<0.001). ConclusionsOur study concluded that university students in Saudi Arabia had significant sleep-cycle difficulties and mild to moderate eye dryness symptoms. Age, female gender, sleep duration, educational level, monthly income, and excessive screen time were found to be associated with sleep-cycle problems and eye dryness symptoms.