Background: The overproduction of thyroid hormones is known as hyperthyroidism. Increased susceptibility to caries and periodontal disease are two potential oral symptoms. The interleukin-6 (IL-6) was observed to significantly increased in the hyperthyroid group. According to multiple research, IL-6 dysregulation has been linked to a number of oral disorders, including periodontal diseases. The study aimed to evaluate periodontal health status in relation to IL6 among hyperthyroidism patients. Subjects and Methods: The sample was composed of 90 female patients aged 25-45 years attending endocrine disorder center in al-Najaf Governorate/Iraq which include hyperthyroid group and healthy group, the hyperthyroid patients were diagnosed by specialist and under treatment with carbimazole. The clinical examination of periodontal health status assessment was performed according to WHO (2013) in addition to evaluation the Plaque and gingival condition. The Saliva was collected to evaluate IL-6 concentrations. Results: Found that the plaque index (PLI) in the study group is more than the control with a significant difference (P<0.05). The gingival index (GI) in the study is more than the control but with no significant difference (P>0.05). Both periodontal pocket depth (PPD) and clinical attachment loss (CAL) are higher in the study group than in the control group, with a significant difference. IL-6 is higher in the study group than in control with a significant difference. There is a positive non-significant correlation between PPD and CAL with IL-6 in hyperthyroid patients Conclusion: The results of the present study showed that individuals with hyperthyroidism are at risk for periodontal disease; these patients have high levels of both periodontal disease and IL6.