Mulberry (Morus spp., Moracecae) is a notable remedial and multi-functional plant. Distinct mulberry types are spread in subtropical, temperate and tropical areas all over the world but the plant mainly is common in China, Korea, India and Asian countries. Mulberry leaves carry a number of bioactive compounds with it along with various pharmacological effects. It is an magnificent origin of nutrients, and phytochemical and is been proven as a nutraceutical. They also act as antioxidant to prevent lipid peroxidation and oxidative stress. Mulberry leaves have a broad extent of therapeutic effects having bacteriostatic, anti-hyperlipidemia, lowering blood glucose, anti-hypertensive, and antiviral properties. The goal of this analysis is to estimate the direct action of extract of mulberry leaves on hyperlipidemic induced rats model. The present study will contribute evidence-based results regarding the antihyperlipidemic effects of mulberry leaves. Previous studies suggest that mulberry leaves is highly effective to manage hyperlipidemia and dyslipidemia due to their lipid ameliorating and antioxidant effect.