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SUMMARY1 The passive permeability of the blood-retinal barrier (b.r.b.) to the water-soluble non-electrolytes, sucrose and mannitol, was determined using a multiple time point-graphical approach as has been used in the assessment of blood-brain barrier (b.b.b.) permeability.2. The calculated permeability surface area product for the b.r.b. for sucrose was 044 (+0-081 S.E. of mean) x 10 -ml g-s1 (n = 20) and for mannitol was 1-25 (±0 30) x 10' ml g-' s-' (n = 18). These values are similar and comparable to those found for the capillaries in the brain (P > 0 05) and significantly different from zero (P < 0-01).3. Data on the concentrations of sucrose in different parts of the eye show that the permeability of the blood-retinal barrier, rather than the more permeable bloodaqueous barrier permeability, was being measured by our technique.

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