Introduction: Cervical cancer (CC) is a public health problem; it is the second most common cause of cancer in Mexico and the third cause of death worldwide. Malnutrition in the cancer patient is present in 80-90% of cases of advanced disease. Objective: To analyze the relationship of the nutritional status of patients with clinical Stage IV and recurrent CC with palliative chemotherapy-associated toxicity. Materials and methods: This was a prospective, descriptive, and observational study. Patients with clinical Stage IV CC recurring on palliative chemotherapy were recruited. Nutritional status was assessed before treatment as well as its relationship with toxicity. Associations between qualitative categorical variables were searched for with Spearman's correlation, and statistically significant differences (p < 0.05) for dichotomous variables were looked for using Fischer's exact test. Results: A total of 17 patients were included, out of which 5 (29.4%) had normal nutritional status, 8 patients (47%) had moderate malnutrition, and 4 patients (23.5%) had severe malnutrition. A positive correlation was found between the degree of malnutrition and the presence of diarrhea (rho = 0.626), nausea (rho = 0.556), and hypoalbuminemia (rho = 0.559). Conclusions: Nutritional status before chemotherapy was shown to be highly important, since a malnutrition status implies higher toxicity by the treatment, which entails an increase in malnutrition for the next chemotherapy session as well as hospital readmissions. (creativecommons.org/licenses/by-nc-nd/4.0/).

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Estado nutricional en pacientes con cáncer cervicouterino tratados con QT/RT concomitante: el efecto de la terapia nutricional en una experiencia de 5 años Emigdio Jaimes-Alpízar Resumen Introducción: El cáncer cervicouterino (CaCu) representa la segunda causa de muerte en la mujer en México, la quimioradioterapia (QT/RT) concomitante presenta diversos cuadros clínicos que afectan el estado nutricional en estos pacientes. Método: Estudio observacional, retrospectivo, descriptivo y longitudinal, en el cual se revisaron expedientes de cinco años y se evaluó el estado nutricional en pacientes con CaCu valorando: peso e índice de masa corporal (IMC), albúmina, hemoglobina, linfocitos y proteínas totales, al inicio y al final del tratamiento. Los datos se analizaron mediante el programa SPSS utilizando la prueba t de Student para variables cuantitativas, se tomó como significancia estadística p ≤ 0.05. Resultados: Se incluyeron un total de 200 pacientes, 170 fueron derechohabientes del Seguro Popular (SP) y 30 pacientes derechohabientes del Instituto de Salud del Estado de México y Municipios (ISSEMyM). S e observó que en ambos grupos existe una disminución del peso significativa, la diferencia absoluta en el grupo ISSEMyM fue de 3.0934 kg, mientras en el grupo SP fue de 3.6583 kg. Discusión: Las pacientes de Seguro Popular presentaron una pérdida de peso grave (> 5%) en un mes (p ≤ 0.05), no siendo así en las pacientes del ISSEMyM, en las cuales la pérdida de peso fue menor al 5% en un mes. Las diferencias entre los valores de hemoglobina, linfocitos, albúmina y proteínas totales para ambos grupos no fueron estadísticamente diferentes. Conclusiones: La terapia nutricional en este grupo de pacientes debe ser obligatoria. Tal y como se demostró en este estudio, la pérdida de peso es menor en las pacientes que la reciben.(creativecommons.org/licenses/by-nc-nd/4.0/). Abstract Introduction: Cervical cancer represents the second cause of death in women in Mexico. Concomitant chemoradiotherapy presents several clinical conditions that affect the nutritional status of these patients. Methods: Retrospective, descriptive, longitudinal, and observational study, in which 5-years histories were reviewed, and nutritional status was eva- PALABRAS CLAVECáncer cervicouterino; Quimioterapia; Radioterapia; Terapia nutricional KEY WORDSCervical cancer;

Introduction: Cervical cancer represents the second cause of death in women in Mexico. Concomitant chemoradiotherapy presents several clinical conditions that affect the nutritional status of these patients. Methods: Retrospective, descriptive, longitudinal and observational study, in which 5-years histories were reviewed, and nutritional status was evaluated in patients with cervical cancer taking into account the following variables: weight, body mass index, albumin, hemoglobin, lymphocytes, and total proteins at the beginning and at the end of treatment. Data were analyzed using the SPSS program, using Student's t-test for quantitative variables. The statistical significance was taken as p ≤ 0.05. Results: A total of 200 patients were included, 170 were beneficiaries of the Seguro Popular (SP) and 30 patients entitled Instituto de Salud del Estado de México y Municipios (ISSEMyM). It was observed that in both groups there is a significant weight loss, being the absolute difference in the ISSEMyM group of 3.0934 kg while in the SP group was 3.6583 kg. Discussion: Patients of Seguro Popular experienced a severe weight loss (> 5%) in one month (p ≤ 0.05), not being so in the ISSEMyM patients, where the weight loss was less than 5% in a month. Values of hemoglobin, lymphocytes, albumin and total proteins were not statistically significant differents between both groups. Conclusions: Nutritional therapy in this group of patients should be obligatory. As demonstrated in this study, weight loss is lower in patients who receive it.