This study aimed to explore the association between nurses' practice environment (NPE), posttraumatic stress disorder (PTSD), and intent to leave among nurses working during the COVID-19 pandemic. BACKGROUND: High levels of physiological and psychological stress in the workplace render nurses susceptible to PTSD. To date, little research has focused on the relationship between NPE, PTSD, and intent to leave during a major health crisis such as the COVID-19 pandemic. METHODS: A cross-sectional online survey was completed by nurses who were members of northeastern and midwestern state nurses' associations. RESULTS: Approximately 44% of nurses sampled indicated a preference for leaving their position. Significant associations were identified between NPE and PTSD and between NPE and intent to leave. CONCLUSION: This assessment of nurses working during the COVID-19 pandemic may inform future mental health strategies and stress management interventions that support nurses continuing to work during a major health crisis.