Aim: Today, antidepressants, which are frequently prescribed by physicians for different purposes, have various effects on ocular tissues. The aim of this study is to evaluate the effects of different agents on the cornea and ocular surface. Material-Methods: For this purpose, 50 healthy controls and 336 patients were included in this study. Results: Compared to the control group, all patient groups had higher OSDI scores and staining scores, and a lower Schirmer test result and a lower tear break-up time (all parameters, p