Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. Exposure to ultraviolet light is an important risk factor for BCC development and the disorder therefore develops commonly on body areas that are more exposed to sunlight, such as the face and neck. It is uncommon in the closed area of the body and quite rare in the perianal and genital regions. Herein, we report a 34-year-old patient with perianal BCC who had no additional risk factors.

A 54-year-old female presented with a 4-month history of extensive dark-colored lesions on her scalp. The pathology result of a previous biopsy from her scalp performed by a general surgeon a year ago had been congenital melanocytic nevus. Dermatological examination showed confluent blue-grey, dark brown macules, papules and nodules covering most of the left parietofrontotemporal scalp in an area measuring 15x30 cm in size ( Figure 1a). There were also satellite lesions of varying diameters on the ear, anterior trunk and one pigmented lesion of the oral mucosa. Dermoscopic analysis of the lesions revealed asymmetry of color and structure, multicomponent global pattern, irregular dots and globules and bluish-white color ( Figure 1b).Histopathologic examination of three 4-mm punch biopsies from the patient's scalp revealed atypical melanocytic lesions with findings that were not adequate to confirm melanoma. Total excision of the scalp lesion was not approved by plastic surgery. The total excision material of the pigmented lesion on her anterior trunk was referred to another pathologist and revealed superficial spreading melanoma with Breslow thickness of 1 mm, Clark level of 3 and mitotic rate of 2/mm² (Figure 1c). In addition, pulmonary metastases were detected by total body positron emission tomography-computed tomography (PET-CT). The case was accepted as T1N3M1 inoperable metastatic malign melanoma originating from the scalp lesion. Vemurafenib treatment was started by medical oncology. However, the patient developed nodules and ulcerations, cervical lymph node metastasis and vena cava superior syndrome during the treatment and died nine months after the diagnosis.

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Türk derm-De ri Has ta lık la rı ve Fren gi Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. Turk derm-Arc hi ves of the Tur kish Der ma to logy and Ve ne ro logy, pub lis hed by Ga le nos Pub lis hing. Özetİmatinib kronik myeloid lösemi (KML) tedavisinde kullanılan ilk moleküler hedeflenmiş ilaçtır. İmatinibin indüklediği advers kutanöz reaksiyonlar sıktır ve genellikle orta şiddetlidir. Diğer taraftan imatinib ile indüklenen eritrodermi nadir olarak gözlenir ve literatürde sadece birkaç olgu yer almaktadır. Bu yayında KML hastasında imatinibin indüklediği eritrodermi olgusu sunulmaktadır. (Türk derm 2014; 48: 54-6) Anah tar Ke li me ler: İmatinib, eritrodermi, deri reaksiyonları Sum maryImatinib is the first molecularly targeted drug developed for the treatment of chronic myeloid leukemia (CML). Adverse cutaneous reactions induced by imatinib are frequent and generally moderate. On the other hand, imatinib-induced erythroderma is an uncommon reaction, and only a few cases have been reported in the literature. In this paper, we report a case of erythrodermia induced by imatinib in a patient with CML. ( OlguYetmiş iki yaşında erkek hasta kliniğimize yüzde şişlik ve vücutta yaygın kızarıklık nedeniyle başvurdu. Hastanın öyküsünden şikayetlerinin ilk kez iki hafta önce yüzde özellikle göz kapakları çevresinde şişlik ile başladığı, birkaç gün sonra da tüm vücutta yaygın kızarıklık geliştiği öğrenildi. Hasta diyabetes mellitus, koroner arter hastalığı nedeni ile uzun süredir repaglinid, metformin, quinapril, asitsalisilik asit aldığını ve son altı haftadır da KML tanısı ile 400 mg/gün imatinib kullandığını belirtti. Hastanın dermatolojik muayenesinde tüm vücutta şiddetli kaşıntının eşlik ettiği yüzde ödem, yaygın eritem, deskuamasyon, bilateral el palmar bölgede ve ayak plantar

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