The methionine/valine (M/V) SNP at codon 129 of the prion protein gene PRNP influences susceptibility to prion diseases. Diack et al. report that vCJD strain properties are not affected by transmission through an individual with the PRNP MV codon 129 genotype, suggesting no association between this genotype and altered virulence.

as a salvage procedure after failed portal vein embolization and portal vein ligation respectively. Results Median increase of FLR volume was 139.25% (range 40.00%-157.78%). Median hospital stay was 28.5 days (range 23-36). Histology report revealed two complete (R0) and two incomplete (R1) resections. Background liver histology revealed steatosis on two occasions and fibrosis on another. 90 day mortality was zero. Two patients developed grade II complications as per Clavien-Dindo classification, one grade IIIa and one IIIb. One patient is disease free after 36 months,. One patient died two years later from viral infection, and two had recurrence in liver and lymph nodes and were treated with microwave ablation and lymphadenectomy respectively. Conclusions ALPPS procedure allows performing major liver resections for high volume neuroendocrine metastases while minimising the risk of post-operative liver failure.

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