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To test for an association with risk for restenosis after coronary stent placement, the TNF-alpha and IL-10 polymorphisms were analyzed by 5' exonuclease TaqMan assays in 162 patients who initially underwent coronary stenting. Analysis of basal and procedure coronary angiographies revealed a higher proportion of restenosis in lesions treated with bare metal stents compared with those treated with drug-eluting stents (P < 0.001). Distribution of TNF-alpha genotypes was similar in patients with and without restenosis. The IL-10 polymorphisms showed a moderate protective trend of the -819 TT genotype against restenosis when the lesions were analyzed (P = 0.071, OR = 0.471). Multivariate analysis confirmed a protective role for drug-eluting stents (P < 0.001, OR = 0.199) and the -819 TT genotype (P = 0.037, OR = 0.391). These results suggest the IL-10 -819 TT genotype has a protective role against in-stent restenosis.

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Se realiza una revisión sobre el riesgo de los pacientes que padecen diabetes mellitus en el contexto de morbimortalidad general y relacionada a infección por el coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2). Así mismo se repasan las recomendaciones generales, de alimentación y de la prevención de las comorbilidades que más frecuentemente padecen dichos enfermos. Finalmente se hace una revisión de las recomendaciones farmacológicas sobre el tratamiento tanto oral como parenteral en el paciente ambulatorio, en la hospitalización y en estados críticos infectados por el SARS-CoV-2.

Rheumatoid arthritis: A case of multivalvular heart diseaseArtritis reumatoide: un caso de enfermedad cardiaca multivalvular Rheumatoid arthritis (RA) is a common chronic, autoimmune disorder, that affects several tissues and organs, principally synovial joints. RA can damage virtually any extraarticular tissue due to a systemic proinflammatory state. 1 The prevalence of RA is of 0.5---1.0% in industrialized countries, 2 Pelaez-Ballestas et al. 3 found a prevalence of 0.7---2.8% in Mexican patients. Rheumatoid nodules present as a local swelling or tissue lump, which occurs almost exclusively in association with RA. Nodules are seen in the heart and usually they are asymptomatic and rarely need surgical intervention. 4 Cardiovascular disease is considered an