No abstract

Highlights d We report the RNA interactome of wild-type and mutant FUS in human motor neurons d Mutant FUS binds the mRNA 3 0 UTR of other RNA-binding proteins, including ELAVL4 d ELAVL4, expressed at increased levels, interacts with mutant FUS in the cytoplasm d ELAVL4 proteinopathy occurs in both FUS ALS and in sporadic ALS patients

Highlights d We report the RNA interactome of wild-type and mutant FUS in human motor neurons d Mutant FUS binds the mRNA 3 0 UTR of other RNA-binding proteins, including ELAVL4 d ELAVL4, expressed at increased levels, interacts with mutant FUS in the cytoplasm d ELAVL4 proteinopathy occurs in both FUS ALS and in sporadic ALS patients