Objective: This study aimed to evaluate Annona muricata's (AM) radioprotective effects on sciatic nerve injury due to ionising radiation (IR). Materials and Methods: Thirty-two adult female Wistar albino rats were separated into four equal groups; Control (C), Annona muricata leaf extracts (AME), radiation (RAD), radiation and AME (AME+RAD). In groups AME and AME+RAD, AME was administered at a dose of 300 mg/kg for the first day and 50 mg/every day for the following one week intraperitoneally. In RAD and AME+RAD, rats were exposed to a single dose of 20 Gray (Gy) IR to their right legs. All the subjects were sacrificed at the end of the first month. Oxidative stress biochemical parameters from blood samples were analysed. In addition, right sciatic nerves were extracted and histomorphology was evaluated. Results: Statistically significant vasculature, degenerative and necrotic changes were observed in RAD, compared to C and AME (p<0.01). Swelling in myelin sheath was predominantly seen in RAD. Alterations in the level of catalase (p<0.01), superoxide dismutase (p<0.01) and glutathione peroxidase (p<0.05) in the AME+RAD group compared to the RAD group were found to be statistically significant. Conclusion: Our study unveiled that AM could potentially enhance biochemical and histomorphological healing in the acute period on sciatic nerve injury due to IR.