A Fe­(OTf)3- and γ-cyclodextrin catalyzed hydroamination of alkenes with carbazoles is demonstrated. This biomimetic-catalyst-oriented sustainable and green method could deliver a wide scope of N-alkylated carbazoles and N-alkylated-carbazole-fused aromatics in up to 97% yield. The salient features of this transformation include simple and benign reaction conditions with no need for a strong base, additive, or the irradiation of light.

A general, efficient, and substrate-controlled regiodivergent trifluoroacetylation of carbazoles has been developed through Friedel–Crafts acylation. This strategy was applicable to a wide scope of readily available substituted carbazoles at air atmosphere without using a metal catalyst, affording the corresponding trifluoroacetylated carbazoles in up to 99% yield. The divergency of the products and the orientation rules have been illustrated based on different substituents on carbazole rings. This method could also be extended to the synthesis of chlorodifluoroacetylated and pentafluoropropionylated carbazoles, which have been achieved for the first time.

The first direct and selective 3,6-di-alkylation of carbazoles via iron-catalyzed hydroarylation of styrenes is demonstrated. This simple, general and efficient method could deliver a wide range of di-benzyl-carbazoles with high...

A simple and efficient methodology for the first synthesis of tri- and di-fluoromethyl-bis(indolyl)-methanols has been demonstrated through the one-pot Friedel-Crafts-type acylation-alkylation of readily available indoles and fluorinated acids. This simple...