ickle cell anemia (SCA) is a common erythrocyte disorder caused by a homozygous point mutation in the hemoglobin beta gene with variable clinical manifestations [1,2]. Sickle cell mutations are common in sub-Saharan African region more-so in Nigeria. Recently, sickle cell disease (SCD) has been declared a public health problem [3]. Studies in the past decades suggest that community knowledge regarding personal sickle cell status and the inheritance pattern of SCD remain inadequate [4,5]. In addition, low-income countries like Nigeria, where the disease is prevalent, lack access to proper and sophisticated diagnostic tools [6]. In Nigeria, screening efforts have remained largely limited to the traditional hemoglobin solubility tests (HSTs) associated with false positives [7]. It is crucial to identify best screening methods for detecting sickle cell hemoglobin in high-risk populations [3,8,9]. To date, no studies have examined the impact of laboratory determined parental sickle cell screening status. The main objective of this study was to compare self-reported parental pre-and post-marital screen results, ascertain the relationship between parental understanding of inheritance pattern of SCA and premarital screening and that between premarital screen result and unwillingness to marry spouse using appropriate statistical tools for inferential and descriptive data. MATERIALS AND METHODS A cross-sectional study was conducted between March 2020 and June 2020 among parents of children with SCA attending the SCD clinic of the