Mucoepidermoid carcinoma is the most common malignant salivary gland tumor in the oral cavity. Primary thyroid involvement is rare, with few cases in the literature. The clinical case describes a patient with squamous cell carcinoma in the hard palate submitted to maxillectomy and lymphadenectomy. Invasion of the thyroid was observed during the surgery, so it was complemented with thyroidectomy. The histopathology resulted in squamous cell carcinoma of the palate with maxillary invasion, papillary carcinoma of the thyroid in the left lobe and mucoepidermoid carcinoma of the thyroid in the right lobe. Mucoepidermoid carcinoma has been found in association with other glandular epithelia of the head and neck.