The morphological surface change of untreated and treated fibers of the Mongolian goat cashmere was investigated by atomic force microscopy (AFM) at ambient conditions. The cuticle scale heights of the Mongolian goat cashmere fibers were measured by the AFM for the fibers before and after treatment. The experimental results showed that the difference between the fine structure of the cuticle and surface roughness of untreated and treated fibers. We found that the surface morphological change of the cashmere fibers was strongly degraded after the bleaching process.

The expression of p53 and beta-catenin proteins in hepatocellular carcinoma (HCC) samples with mutations in the tumor suppressor TP53 gene, which has a high frequency of mutations in liver cancer, and the CTNNB1 gene, which plays an important role in the Wnt signaling pathway, were identified. As a result, the beta-catenin protein was increased in 83.33% of liver tumor samples with CTNNB1 gene mutation, and p53 protein expression was increased in 50% of samples with TP53 gene mutation. According to this, it may be that liver tumors were caused by changes in p53 and beta-catenin protein expression. Элэгний хорт хавдрын эсийн p53, бета-катенин уургийн экспресс Элэгний хорт хавдрын мутацийн өндөр давтамжтай тохиолддог хавдар дарангуйлагч ТР53 ген болон Wnt дохиоллын замд чухал үүрэгтэй оролцдог CTNNB1 генийн мутаци илэрсэн элэгний хавдрын дээжүүдэд уургийн (p53, бета катенин) нийлэгжлийг вестерн блотын аргаар судлав. Судалгааны дүнд CTNNB1 генийн мутацитай элэгний хавдрын дээжүүдийн 83.33%-д бета-катенин уураг, ТР53 генийн мутацитай дээжүүдийн 50%-д р53 уургийн нийлэгжил тус тус нэмэгдсэн байв. Үүнээс үзэхэд p53 болон бета-катенин уургийн нийлэгжлийн өөрчлөлтөөр элэгний хавдар үүссэн байх магадлалтай. Түлхүүр үгс: мутаци, хавдар, вестерн блот

In this study, the morphological changes of chemically treated (or preserved) with aqueous solutions of 1) a sodium chloride (NaCl) and 2) a compound containing sodium silicate, so called “wasserglass”, and untreated I-type collagen fibers of Mongolian goatskin are investigated by atomic force microscopy in ambient condition and at room temperature. The experimental results show that the difference between D period for both chemically treated and untreated collagen fibers are a relatively stable for morphological behavior. However, we find that the width of collagen fibers treated with the NaCl solution is more increasing with approximately 112 nm than those of samples (untreated and treated with wasserglass solution) for the range 93.4-94.8 nm. We also observe that a typically structure of the collagen fibers generally, a dense packing of the untreated and treated by wasserglass collagen fibers in bundles in a nearly parallel arrangement, with little changes in orientation can be seen. The collagen fibers treated by NaCl are a more destructive than untreated and treated by wasserglass for collagen fibers.