Context: Persia has been the cradle of science across human history. Many of today’s concepts in science, such as the finite speed of light and alcohol distillation, were first proposed by Persian scientists. Mohammad ibn Zakariya Razi (Rhazes) is undoubtedly one of the greatest Persian scientists over human history. Evidence Acquisition: In this paper, in addition to a brief review of the history of pharmacy and chemistry sciences in Persia, Rhazes’ valuable books in the fields of pharmacy and chemistry, along with a brief description of them, were introduced. Data were extracted from different historical and bibliography books and also the citation databases of PubMed, Scopus, and Google Scholar. Results: Rhazes’ books and treatises in the fields of pharmacy and chemistry have been classified into three categories: 1) the books and treatises containing some sections on pharmacy like Al-Hawi fi al-Tibb (Liber Continens) and Al-Mansouri fi al-Tibb, 2) those written merely on pharmacy, like Qarabadin (pharmacopeia), and 3) the books focusing on alchemy (kimia), like Sirr al-Asrar (Secret of secrets) and Al Asrar (Liber Secretorum). Three volumes of Al Hawi fi al-Tibb were applied as a reference in pharmacology in Western universities for many years. Sirr al-Asrar is his most important book on alchemy, describing raw materials used in alchemy, experimental apparatus necessary for alchemical investigations, and detailed procedures for the chemical manipulation of arsenic and sulfur. Conclusions: These valuable manuscripts demonstrate the ancient heritage of Persians and the great roles and contributions of Persian scientists in the history of science.