Background and objective: Schizophrenia requires preservation of treatment with psychotropic medication and psycho-educational therapy. The nurse uses effective strategies to train those patients about stress management; relaxation technique and increase self-awareness, to improve their quality of life and enhance antipsychotic adherence. The study aimed to assess the effective strategies for nurses empowering the life quality and antipsychotic adherence of patients with schizophrenia.Methods: Quasi-experimental research design was utilized in this study. The present study was achieved at the outpatient departments of the Mental Hospital in Beni-Suef, Egypt. A non-probability sampling of 60 patients with schizophrenia were recruited for the study. Tools of this study included: A structured interview questionnaire related to soci-demographic data, the quality of life scale, and the medication adherence rating scale. The training program consisted of 8 sessions.Results: The study indicated that there were statistically significant improvements in the life quality and antipsychotic adherence for patients with schizophrenia after application of psychiatric nursing instructions.Conclusions and recommendations: The results of this study concluded that psychiatric nursing approaches were effective in the improvement the quality life and adherence to antipsychotic of patients with schizophrenic disorders. Recommendations: This study recommended that a psychiatric nurse must use the effective strategies for empowering the life quality and antipsychotic adherence of patients with schizophrenia.