Ставропольский государственный медицинский университет, Россия 2 Уральский государственный медицинский университет, Екатеринбург, Россия 3 Первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский университет), Россия

No abstract

Tuberculosis in children of early and preschool age with herpesvirus infection. Moscow, 2013. (In Russ.)]. 13. Давис Н. А., Исламова Н. Н., Парпиева Н. Н. [и др.]. Влияние сопутствующих кишечных паразитозов на некоторые показатели иммунного статуса у больных туберкулезом легких. Туберкулез и болезни легких. 2012;3:47-50. [Davis N. A., Islamova N. N., Parpieva N. N., Belocerkovec V. G., Osipova S. O. Vlijanie soputstvujuwih kishechnyh parazitozov na nekotorye pokazateli immunnogo statusa u bol'nyh tuberkulezom legkih. Tuberkulez i bolezni legkikh.-Tuberculosis and lung diseases. 2012;3:47-50. (In Russ.)].

The purpose of research. Predicting risk of infection of acute destructive pancreatitis. Material and Methods. The dynamics of functional activity of granulocytes in 27 (58,7%) patients with sterile and 19 (41,3%) patients with infected pancreatic necrosis. An objective assessment of the severity of their condition carried out by performed using of the scale of the integrated assessment APPACHE-II. The exclusion criterion from the study was the revealing of accompanying acute and chronic diseases. Results.Scale APPACHE-II can be used mainly for screening assessment of the degree of polyorgan insufficiency, as well as predicting the development of infected pancreatic necrosis forms, but, unfortunately, only in the later stages of development of pathological process. Dynamics of changes in the functional activity of leukocytes in patients with pancreatic necrosis can be used as an additional test, which characterizes the moment of transition of sterile pancreatic necrosis to infected, and, consequently, in deciding on the timing of terms and nature of performance of operational allowance. Conclusions. 1. In patients with sterile pancreatic necrosis (SPN) after a moderate decrease in the activity of myeloperoxidase (MPO), the content of the cation proteins (CP) in the first three days in subsequent periods of observation, on the background of complex conservative therapy, noted, compared with the established "Normal" gradual increase or stabilization at close to the indicators of the functional activity of neutrophils. The activity of KF and alkaline phosphatase from patients with SPN, after the increase in performance in the first 11 days, then gradually declines, reaching the normal level. 2. Patients with infected pancreatic necrosis(IPN) sharply, starting with 11 days of the study, by 35-40%, reduce the activity of MPO and the content of CB and Acid Phosphatase activity and Alkaline Phosphatase, on the contrary, it had progressively pronounced growth after 11 days by 35-40%.

2 первый московский государственный медицинский университет им. И. м. Сеченова (Сеченовский Университет), Российская Федерация 3 Городская больница, Кисловодск, Российская Федерация 4 Ставропольский государственный медицинский университет, Российская Федерация 5 Республиканский онкологический диспансер, Республика Северная Осетия-Алания, Владикавказ, Российская Федерация surgical managemenT of choledocholiThiasis Totikov V. Z. 1 , shulutko a. m. 2 , Toboev d. V. 5 , Totikov Z. V. 1 , natroshvili a. g. 2 , natroshvili i. g. 3 , Baychorov e. h. 4 , moiseev a. Yu. 2 , Voitkovskii a. e. 4 1 north-ossetian state medical academy, Vladikavkaz, russian federation 2 i. m. sechenov first moscow state medical university (sechenov university), russian federation 3 municipal hospital, Kislovodsk, russian federation 4 stavropol state medical university, russian federation 5 republican oncological dispensary, republic of north ossetia-alania, Vladikavkaz, russian federation Для анализа результатов одно-и двухэтапного методов хирургического лечения холецистохоледохолитиаза проведено ретроспективное исследование 1076 больных, оперированных в плановом порядке в хирургических клиниках Владикавказа, Москвы и Кисловодска с 1997 по 2014 год. Успешная санация общего желчного протока достигнута у 98 % пациентов, общее число осложнений составило 8,0 %, послеоперационная летальность-0,28 %. При достаточном опыте хирургов современные малоинвазивные технологии позволяют надежно и безопасно использовать одномоментную тактику хирургического лечения холецистохоледохолитиаза. Статистически достоверной разницы в эффективности и безопасности одно-и двухэтапного алгоритмов хирургического лечения холецистохоледохолитиаза настоящее исследование не выявило. Ключевые слова: холедохолитиаз, желчнокаменная болезнь, лапароскопическая холедохолитотомия To evaluate the results of single and two-stage management of choledocholithiasis we performed retrospective analysis of 1076 patients undergone surgery in hospitals of Vladikavkaz, Moscow and Kislovodsk in 1997-2014. Successful debridement of the common bile duct was achieved in 98 % of patients, the total number of complications was 8.0 %, postoperative mortality was 0.28 %. Experienced surgeon can use single-stage algorithm safely and effectively. The present study did not reveal a statistically significant difference in the efficacy and safety of single-and two-stage management of cholecystocholedocholithiasis.