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Alkaptonuria or Ochronosis is an autosomal recessive congenital metabolic error due to absence of enzyme homogentisic acid oxidase. Recently, we had an opportunity to diagnose this condition in one of our patients. An old aged man developed a pathological fracture of femur after a trivial fall at home. He was diagnosed to have intracapsular fracture neck of femur. Intraoperatively we noticed blackish discoloration of femoral head which lead us to investigate the case for alkaptonuria. Hemiarthroplasty was done with Austin moore prosthesis. Patient had cutaneous pigmentation and gross arthritic changes at multiple joints including spine. After one and half year patient developed a periprosthetic fracture of the femur for which open reduction and internal fixation was done. A periprosthetic fracture in ochronotic patient has never been reported till date which makes it a rarer entity. This article presents the clinico-radiologic manifestations of the case with surgical management and a follow up of two years.

BACKGROUND Ovarian cancer is the 6 th most common cancer in worldwide among female population, whereas in India, it is the third most common cancer among women, 1 in 70 women have their lifetime risk to develop this tumour. Survival rate depends on the stage of diagnosis. Although, geographic and racial differences in the incidence of ovarian tumours are well-recognised information regarding any dissimilarity in clinicopathological behaviour is scarce. In the present study, the clinicopathological features of patients with ovarian tumours are evaluated. MATERIALS AND METHODS In a series of 96 clinically and diagnostically-proved ovarian tumours, case history was taken and clinical examination was done. Surgical staging done according to laparotomy, gross morphology and histopathological study was done. Study Type-Observational study, done in between December 2015-March 2017 in Konaseema Institute of Medical Sciences and RF (Research Foundation). RESULTS Out of 96 cases are studied in Konaseema Institute of Medical Sciences and RF, 59 cases are benign and 32 cases are malignant tumour and 5 cases are borderline malignant potential tumours. Most of the tumour presented within 2 months of onset of symptoms, abdominal distension is commonest presentation in (51% of cases). Almost, 71% of the malignant tumour diagnosed at stage III/IV of the disease. CONCLUSION On histopathological study of these tumours, 73% are surface epithelial tumours. Among surface epithelial tumours, serous tumour is the commonest one. So, early diagnosis and prompt treatment (surgery and chemotherapy) definitely reduce the mortality from ovarian tumour.