IMPORTANCEEndurance exercise is effective in improving peak oxygen consumption (peak V ˙O2 ) in patients with heart failure with preserved ejection fraction (HFpEF). However, it remains unknown whether differing modes of exercise have different effects. OBJECTIVE To determine whether high-intensity interval training, moderate continuous training, and guideline-based advice on physical activity have different effects on change in peak V ˙O2 in patients with HFpEF.
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