After the landfill site is sealed, the uneven settlement is related to the safety of reutilisation of the site, and it is critical to calculate the uneven settlement of the site without error. In this article, the soil parameter of garbage body was changed with biodegradation. Fast Lagrangian Analysis of Continua in three dimensions (FLAC 3D) numerical simulation was applied to the settlement of the landfill site closure. In calculating the settlement of landfill, the soil parameters of landfill with age were obtained by field drilling experiments. The parameters can reflect the characteristics of soil organic matter in different biodegradation stages. Finally, the uneven settlement within 20 years of the closure period was obtained by the numerical simulation taking Jinzhou Nanshan landfill as an example. The results show that the settlement with the age increases gradually, but the rate will be more and more moderate, and the maximum subsidence value in the sealing field after 20 years will be 9.11 m, 15.71% of the maximum elevation. Around the landfill slope position of uneven settlement rate is bigger, and the maximum angle of uneven settlement is up to 45°. But the middle position is small, which is close to 0°.