This paper shows space syntax as a useful tool for evaluating buildings as well as for research on environmental perception. With this methodology, the spatial organization of a building was measured, obtaining a quantitative description of the relationships among the spaces within the building. This measurement is given in terms of how closely each space of the building is connected with the others. We analysed the relationship between the level of integration of each space and the perception of the settings in terms of way finding, communication, and ease of displacement. The results showed that 39% of the variance of perception is explained by the spatial configuration of the building. It suggests that space syntax measures could be helpful in foreseeing how people perceive spatial orientation.