Hematogenous metastasis of liposarcoma to the heart is rare, even though other types of distant metastatic cardiac tumors are relatively more common than primary cardiac tumors. We experienced a case of distant metastasis of liposarcoma to the right interatrial septum, mimicking lipomatous hypertrophy in transesophageal echocardiography (TEE). There were no significant findings in the preoperative transthoracic echocardiography (TTE) or computed tomography (CT). TEE was the only tool to suspect the presence of a cardiac tumor. It also helped evaluate the spread of tumor invasion and make a decision for operation.