Thrombocytopenia is the result of falling the number of platelet from 150,000/microL. There are three main reasons of thrombocytopenia, a-Decreasing of making platelet b-Increasing of destruction platelet c-Changing of distribution platelet.

Background: Chemotherapy-induced nephrotoxicity is an important handicap for optimal treatment. For this reason, we need useful markers for early detection of chemotherapy-induced renal disfunction. This study was performed to investigate the relationship between the plasma natriuretic peptides' (ANP and BNP) levels and chemotherapy-induced nephrotoxicity.