Serotonin at a dose of 200 μg given to normal chickens by unilateral leg vein infusion showed an ipsilateral excess of excretion. The excess excretion was below 10 per cent of the dose however. Birds pretreated with a mono amine oxidase inhibitor showed an ipsilateral excess of such a magnitude (26 per cent of the injected dose) that it proves a tubular excretion of serotonin. Reserpine failed to block this process, but a small blocking effect of reserpine cannot be excluded. Urine flow was not significantly altered by the dose of serotonin used in this study.

SANNER, E. Studies on the excretion mechanism of serotonin (5-hydro%j,tcyptamine) in the chicken kidney. Acta physiol. scand. 1963.58. 330-341. -Serotonin at a dose of 150-200 ,ug was injected into the leg vein of the chicken together with phenol red and tolazoline. All birds Xvcrc pre-treated with a M.40 inhibitor (JB-516, Catronm). The tubnlar excretion of serotonin was inhibited by simultaneous administration of tolazoline at a dose of 5-15 mg into the leg vein. Probenecid at a dose of 50 mg/kg given into the wing vein 1 hour prior to serotoninphenol red injections gave a strong inhibition of phenol red excretion but left the serotonin excretion unchanged. Brom cresol green at a dose of 1 mg caused a specific inhibition of phenol red transport but left serotonin transport unchanged. Cyanine dye # 863 at a dose of 2 mg did inhibit the serotonin transport but such a big dose also interfered with phenol red transport capacity. Smaller doses of cyaninc dye gave a weak inhibition of serotonin transport and did not alter the phenol red transport to any great extent. Reserpine did not inhibit either serotonin or phenol red transport. pH of the chicken urinc did not influence the excretion of srrotonin.

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A follow-up study was made of 29 patients aged 21 to 45 years, some 15-158 months after acute myopericarditis. The mean follow-up period was 72.9 months. The follow-up investigation included recording of history, physical examination, laboratory tests, radiologic examination of the heart and lungs and electrocardiography. All hut one of the patients were fit for fulltime work. Nine had residual cardiac symptoms, but the physical examination was negative in all but 2 of them. One patient had chronic cardiac insufficiency and hepatic enlargement. Another had sinus tachycardia and cardiac enlargement of moderate degree and impaired working capacity in relation to heart size. Cardiac murmurs without clinical significance were audible in three cases. The resting ECG was pathologic in only 6 cases. Orthostatic ECG evoked ECG abnormalities in 6 more cases. Exercise tolerance tests showed reduced working capacity in relation to heart volume in 5 of the 29 cases (17%). Four of these 5 patients had cardiac enlargement. There was thus good correlation between increase in heart volume and reduction of physical capacity. The prognosis in regard to cardiac function was good, as was also found in other comparable series in which the observation time was somewhat shorter.