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Metoclopramide HCl is used to relieve nausea and vomiting. Market availability in the form of tablets, syrup and injection. The most preferred drug use by patients is oral medication because of its ease of use. Chewable tablets are a new product as an alternative for treatment in pediatric and adult patients who have difficulty swallowing drugs. This study aims to formulate the chewable tablet preparations of metoclopramide HCl using variations in lubricant concentrations. The variations of magnesium stearate with concentrations of 1%, 2%, and 3% using the direct printing method made to obtain a better physical quality test including organoleptics, weight uniformity, uniformity of size, tablet hardness, tablet brittleness, tablet crush time, uniformity of content. The results of the physical quality test were statistically analyzed using one way ANOVA to determine the effect of variations in the concentration of lubricants on the characteristics of chewable tablets. The results showed that variations in the concentration of magnesium stearate lubricant in the manufacture of metoclopramide HCl chewable tablets had an effect on the physical quality of metoclopramide HCl chewable tablets. The concentration of magnesium stearate which produces metoclopramide HCl chewable tablets with good physical properties is 2%.

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Batuk merupakan salah satu respon tubuh dalam mengeluarkan dahak dan digunakan sebagai salah satu sistem pertahanan tubuh. Pilek merupakan gangguan kesehatan pada saluran pernafasan bagian atas yang dapat disebabkan oleh beberapa hal meliputi infeksi dan alergi. Penelitian ini bertujuan untuk mengetahui presentase kandungan obat batuk pilek yang dikonsumsi anak-anak, dan obat batuk pilek kombinasi yang banyak digunakan. Metode penelitian yang digunakan adalah penelitian deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data yang digunakan adalah menggunakan kuisioner. Hasil penelitian ini menunjukkan bahwa kandungan sirup obat batuk pilek pada anak yang sering digunakan adalah guaifenesin sebanyak 20,5%, gliseril guaicolat sebesar 12,6%, pseudoefedrin sebesar 36,8%, phenylpropanolamine sebesar 5,4%, dan dextromethorphan sebesar 24,7%.