Thirty nine pcdiolric patients with chronic idiopathic thrombocytopenic purpura have been followed by the same medical team of a university associated children's hospital from Santiago, Chile, for a total of 25 years. Pat'enrs were treated with a slep by stop protocol lhat included observation, prcdnisone, splenectomy and immunosuppressors. Twenty ihrcc palients [59%) eventually recovered. 48% did it spontaneously, 17% afler prednisone treatment, 3"% alter splenectorny and 4% after all precedent methods and immunosuppressor drugs trealment. The therapeutical decissions were always taken depending on the clinical evolution and nol after prestablished time schedules.(