We conclude that parents share important misconceptions about definition, treatment, and consequences of childhood fever and tend to treat fever before seeking medical care with a substantial rate of wrong doses and wrong intervals.

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BackgroundBehçet's disease (BD) is a multisystemic inflammatory disorder classified as vasculitis, which can affect all types of vessels. The prevalence of vascular involvement has been reported at rates ranging from 15 to 50%.ObjectivesIn this study, we aimed to determine the characteristics of vascular involvement in patients with BD.MethodsSix hundred and ninety-two patients with BD, who applied to the multidisciplinary BD policlinic between 2006–2016, were retrospectively analyzed. The diagnosis of vascular involvement was made on clinical signs, by Doppler ultrasonography and/or angiography using computed tomographic or magnetic resonance techniques where appropriate.ResultsOne hundred and seventy-six patients (%25.4) had vascular involvement. The mean age of patients with vascular involvement (n=176) and non-vascular involvement (n=516) was similar to 42.5±12.3 and 42.2±12.2 years, respectively, while male sex frequency was significantly higher in patients with vascular involvement (72% to %42, p<0.001). Uveitis (45%) and erythema nodosum (EN) (47.7%) were significantly higher in patients with vascular involvement than those without vascular involvement (for Uveitis OR: 1.7, p=0.003/for EN: OR: 2.5, p<0.001) (Table 1). Deep vein thrombosis was detected in 142 (80.7%) of the patients with vascular involvement and this was the most common type of vascular involvement (Table 2). Arterial involvement was detected in 52 (29.5%) of 176 patients with vascular involvement. Deep venous thrombosis alone was present in 125 (71%) patients, arterial involvement alone in 12 (6.8%) patients, arterial and venous involvement together detected in 40 (22.7%) patients. Arterial involvement was most commonly seen as pulmonary artery involvement in 45 (25.6%) patients [pulmonary artery thrombosis 35 (20%), aneurysm 10 (5.7%) and thrombosis + aneurysm 6 (3.4%) patients]. Twenty (11.3%) patients had other arterial involvement except pulmonary, 8 of them had thrombosis and 12 had aneurysm.Table 1.Clinical features in patients with and without vascular involvementWith vascular involvementWithout vascular involvementOR95% CIP value n (%)176 (25.4)516 (74.6)Age (year)42.5±12.342,2±12.20.762Male n (%)127 (72.2)217 (42.1)3.572.46–5.19 <0.001 Genital ulceration n (%)123 (69.9)392 (76.1)0.7280.498–1.0650.101Uveitis n (%)79 (44.9)166 (32.4)1.6981.196–2.409 0.003 Papulopustular erythema or acneiform rash n (%)101 (51.4)186 (57.4)1.2740.886–1.8320.190EN n (%)84 (47.7)98 (27.1)2.4601.689–3.582 <0.001 Table 2.Venous involvement (%)Deep vein thrombosis142 (80.7)Budd-Chiari syndrome7 (4.0)Inferior and superior vena cava syndrome26 (14.7)Iliac vein thrombosis18 (10.2)Safenous vein thrombosis23 (13.1)Femoral vein thrombosis36 (20.5)Popliteal vein thrombosis43 (24.4)Crural vein thrombosis12 (6.8)Cerebral sinus thrombosis20 (12,2)ConclusionsVascular involvement in Behçet's disease is commonly seen in males. Deep vein thrombosis is the most common form of vascular involvement. Arterial involvement is important because of its higher risk of mortality ...

BackgroundBehçet’s disease (BD) is an inflammatory disease with chronic systemicvasculitis. The disease is characterised by attacks of oral and genital ulcers, skin lesions, arthritis, uveitis and deep vein thrombosis. The main histopathologic feature is known to be vascular inflammatory changes. Calprotectin is expressed by granulocytes, monocytes and endothelial cells, and produce an inflammatory response in human microvascular endothelial cells.ObjectivesThe aim of this study was to evaluate serum calprotectin levels and their relationships with disease-related variables in patients with BD.MethodsForty-eight patients diagnosed with BD according to International Study Group of BD classification criteria and 22 demographically matched healthy control subjects participated in this study. Calprotectin levels were measured in blood samples from patients and controls. The disease durations of the patients were between 1 and 28 years. The Behçet’s Disease Current Activity Form (BDCAF), that scores the history of clinical features presenting during four weeks prior to the day of assessment, and Behçet’s Syndrome Activity Scale (BSAS) were used for the evaluation of disease activity.ResultsMean serum calprotectin levels were significantly higher in patients withBD compared to the control group (60.6±43.8, 37.6±37.5, respectively; p=0.037) (Figüre 1). Distribution of age (years; 40.6±12.9, 46.6±11.4, respectively; p=0.075) and sex (male; 62.5%, 45.5%, respectively, p=0.191) between these groups were similar. In the comparison of the calprotectin levels of the patients with or without the components of BD, we found significantly higher levels of calprotectin in patients with oral and genital ulceration versus without these involvements (table 1). Since there were only 2 uveitis patients in this patient group, no calculations were made on uveitis. Serum calprotectin was significantly associated with BDCAF, BSAS, patient’s impression of disease activity, clinician’s impression of disease activity, ESR (Erythrocyte sedimentation rate) and CRP (C-reactive protein) (table 2).Abstract THU0610 – Table 1Comparison of calprotectin levels of patients with or without the components of disease activity(n)Calprotectin (ng/ml)P value Oral ulcerationyes29 no1973.2±46.241.4±32.30.007Genital ulcerationyes9 no3994.5±45.652.8±40.00.009Erythema nodosumyes5 no4382.9±45.158.0±43.50.23Skin pustulesyes18 no3066.0±48.757.3±41.10.51Arthritisyes15 no3357.5±43.162.1±44.70.74Vascular activationyes9 no3959.5±52.360.9±42.40.93Abstract THU0610 – Table 2Correlation between calprotectin level and disease characteristics in patients with BDCalprotectinp BSAS0.4090.004BDCAF0.3750.009Patient’s impression of disease activity0.4010.005Clinician’s impression of disease activity0.3850.007ESR0.4400.002CRP0.3120.031Abstract THU0610 – Figure 1Serum calprotectin levels in BD and control groupsConclusionsOur study demonstrated that serum calprotectin levels were significantly higher in patients with BD relative to the control group, and were significantly correlated...