Aim:To analyze the colposcopic examinations and cervical histopathology results of women who presented at our clinic with abnormal PAP-smear and/or human papilloma virus (HPV) positivity. Material and Methods:A retrospective examination was made of the colposcopy findings, number of punch biopsies, and final histo-pathological results of patients who presented at the gynecology polyclinic between January 2018 and January 2020 with a smear result showing atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesions (LGSIL), high-grade squamous intraepithelial lesions (HGSIL), and atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H), and/or HPV test was 16, 18 and other types of positivity. The Chi-square test was applied in the comparisons of the findings.Results: Evaluation was made of 214 patients with a mean age of 46.54±10.76 years. The PAPsmear results were recorded as ASCUS in 71 (33.2%) patients, ASC-H in 2 (0.9%), LGSIL in 23 (10.7%), HGSIL in 8 (3.7%) and normal or showing inflammation in 110 (51.4%). HPV 16 positivity was determined in 58 (27.1%) patients, HPV 18 positivity in 12 (5.6%), other high-risk type (HR-) HPV positivity in 84 (39.3%) and other type HPV positivity in 53 (24.8%). The colposcopy findings were recorded as leukoplakia in 60 (28%) patients, a punctuation appearance in 40 (18.7%), mosaic appearance in 26 (12.1%), and atypical vascularization in 24 (11.2%). We detected that biopsy was taken from all the colposcopies we made. A single punch biopsy was taken from 53 (24.8%) patients, and multiple biopsies were taken from 161 (75.2%). The histo-pathological results were reported as LGSIL in 45 (21%) patients, HGSIL in 15 (7%) and carcinoma in 1 (0.5%). No correlation was determined between the colposcopic examination findings and the number of punch biopsies (p=0.655). As the number of punch biopsies increased, so the probability of LGSIL, HGSIL and carcinoma increased (p=0.006). Conclusion:Leukoplakia was the most common colposcopic finding. Gynecologists were in favor of taking multiple biopsies in the clinic. LGSIL was the most encountered histo-pathological result. Colposcopy examination findings did not affect the number of punch biopsies, but it was observed that the possibility of detecting cervical premalignant and malignant lesions increased as the number of punch biopsies increased.

Edinsel hemofili A, hemofili aile öyküsü olmayan bireylerde endojen faktör VIII (FVIII)'e karşı gelişen oto antikorlar sebebiyle oluşan nadir bir kanama bozukluğudur. İnsidansı milyonda 1,30-1,50 olarak bildirilmiştir. Klinik olarak spontan kanama riskinin yüksek olduğu ciddi hemofili A'ya benzer ancak kanamalar daha çok mukokütanöz, yumuşak doku veya gastrointestinal kanama şeklindedir. İnhibitör gelişimi Hemofili A vakalarında önemli sorunlardan biridir. Edinsel hemofili A tedavisinde birinci seçenek tedaviler baypas yapıcı ajanlardır. Bu amaçla rekombinant faktör VIIa ve aktive protombin kompleks konsantreleri kullanılmaktadır. Burada edinsel hemofili A ve faktör VIII inhibitör pozitifliği olan bir olgu sunulmuştur.