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Neutrophil, plays an important role in innate immune response, that phagocytebacteria, will burst of oxygen consumption (respiratory burst), and produce reactiveoxygen type as bactericidal or by produce of lysis enzymes (non oxygen dependent).Phagocytes are the important factors that play a role in acute inflammatory responsedue to their ability to destroy various pathogens efficiently. Gingival changes inpregnancy have been attributed to changes in sub gingival biofilm related to hormonalvariation.Aim of the study: To evaluate the neutrophils count in both saliva and blood, alsodetermined the phagocytic activity of neutrophil in pregnant at different stages andnon-pregnant women the study the association of neutrophile changes withseverity of some oral disease including gingivitis and plaque.Material and methods: twenty four pregnant women as study group and fourteennon pregnant women as control group were included in this study. The pregnantwomen were following up for three groups according to pregnant stages .Plaqueand gingival indicates. Saliva and blood samples from pregnant women atdifferent stages and control group (non pregnant women) were obtained andneutrophils total number was determine by using Neubauer chamber so theneutrophils number were carried out for all subjects . The phagocytic activities ofneutrophils were examined after challenged the neutrophils with candida albicansthat had been opsonized.Conclusion: salivary and blood neutrophils counting and phagocytic function aresignificantly increase in women at third trimester and positively associated withthe severity of plaque and gingivitis..

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