In this research we study two simple methods, rapid of use spectrophotometric determination of sulphadimadine sodium (SDMS). The fi rst method based on diazotization of drug by sodium nitrite at 5Cº followed by coupling with Salicylic Acid in basic medium to form yellow color. The product was measured at 453 nm. Beer's law is obeyed in the concentration range of (1-16) μg•ml -1 . Sandell's sensitivity was 0.07575 μg•cm -1 , the detection limit was 0.3992 μg•ml -1 , and the limit of Quantitation was 1.07879μg•ml -1 . The second method was used cloud point extraction (CPE) with used Triton X-114 as surfactant. Beer's law obeyed in the range of concentration was (1-12) μg•ml -1. Sandell's sensitivity was 0.04 μg•cm -1 , the detection limit was 0.0259 μg•ml -1 , and the limit of quantitation was 0.029563 μg•ml -1. All variables were study including of the reagent concentration, reaction time. The composition of product (1:1). The methods were effectively useful to the determination of SDMS in pharmaceutical dose form, and the attained results were in good agreement with the offi cial and other methods in literature .No interference was observed from the commonly encountered additives and recipients.

Two simple methods spectrophotometric were suggested for the determination of Cefixime (CFX) in pure form and pharmaceutical preparation. The first method is based without cloud point (CPE) on diazotization of the Cefixime drug by sodium nitrite at 5Cº followed by coupling with ortho nitro phenol in basic medium to form orange colour. The product was stabilized and measured 400 nm. Beer’s law was obeyed in the concentration range of (10-160) μg∙mL-1 Sandell’s sensitivity was 0.0888μg∙cm-1, the detection limit was 0.07896μg∙mL-1, and the limit of Quantitation was 0.085389μg∙mL-1.The second method was cloud point extraction (CPE) with using  Trtion X-114 as surfactant. Beer’s law was obeyed in the concentration range of (10-160) μg∙mL-1. Sandell’s sensitivity was 0.1470μg∙cm-1, the detection limit was 0.06680μg∙mL-1, and the limit of quantitation was 0.07293μg∙mL-1. All variables including the reagent concentration, reaction time, colour stability period, and mole ratio were studied in order to optimize the reaction conditions. The composition of product (1:1). The methods were effectively useful to the determination of Cefixime in pharmaceutical dose form, and the attained results were in good agreement with the official result and other methods in literature .No interference was observed from the commonly encountered additives and excipients

A new spectrophotometric method for the determination of allopurinol drug was investigated. The proposed method was based on the determination of allopurinol in pharmaceuticals. The method relies on the interaction of metal ions with allopurinol in an alkaline medium to form a micelles extracted from a non-ionic surfactant (Triton X-114) and allopurinol-Ag II at a maximum of 906 nm. Experimental variables were performed individually to obtain high extraction efficiency for both compounds. Under optimal conditions, Beer's law was obeyed in the concentration range of 5-35 μg ml -1 ( r=0.9997) the detection limits of 0.245951 μgml -1 The proposed method was applied successfully for the determination of allopurinol drug in pharmaceuticals with a good accuracy and precision. The optimum condition for the colour development has also been investigated.