The work examined the impact of information technology (IT) tools on supply chain performance of online retailers in Calabar Metropolis, Cross River State. The study adopted the cross-sectional survey research design and the purposive sampling procedure. Data were analyzed using the multiple regression analysis. The study revealed that information technology (IT) tools have positive influence on supply chain performance of online retailers in Calabar Metropolis. It has been observed that the use of information technology improves supply chain performance as it assists the online retailers in building accumulative knowledge about various supply chain partners (customers, suppliers, distributors, and main channels). The study concluded that supply chain management begins and ends with the customers. And, the sole aim of the integration and collaborations of the supply chain is to effectively and efficiently satisfy customers' demands and needs, as well as add value to the supply chain activities which would enhance their performance. The study therefore, recommended that online retailers should build an effective supply chain, integrated with information technologies enabled logistic system that can improve supply chain performance and response quickly to unexpected needs of the consumers.