Contingent screening for trisomies 21 and 18 by cfDNA testing at 11-13 weeks is feasible and has a lower IT rate than combined testing alone.

In spite of good correlation between MMSE and MEC, both detect different CI prevalences with the cut-off point at 23/24. Their agreement is only moderated in practice, because we interpret tests in a dichotomic way (CI versus no-CI). In our experience, we cannot use them indistinctly with the cut-off point at 23/24, especially in subjects with low educational level or aged 80 or more years.

Background:Chronicity, and particularly complex care needs for people with chronic diseases is one of the main challenges of health systems.Objective:To determine the population prevalence of people with chronic diseases and complex care needs and to characterize these needs considering features of health and social complexity in Primary Care.Design:Cross-sectional population-based study.Scope:Patients who have one or more chronic health conditions from three Primary Care urban centres of a reference population of 43.647 inhabitants older than 14 years old.Methodology:Data will be obtained from the review of electronical medical records. Complexity will be defined by: 1) the independent clinical judgment of primary care physicians and nurses and 2) the aid of three complexity domains (clinical and social). Patients with advanced chronic disease and limited life prognosis will be also described.Conclusions:This research protocol intends to describe and analyse complex care needs from a primary care professional perspective in order to improve knowledge of complexity beyond multimorbidity and previous consumption of health resources. Knowing about health and social complexity with a more robust empirical basis could help for a better integration of social and health policies and a more proactive and differentiated care approach in this most vulnerable population.

Workload can be predicted by patients' clinical characteristics. The positive correlation of workload with variables related to disease severity and the negative correlation with variables related to cognitive impairment show that home care nursing in Catalonia is basically demand-oriented.

The cognitive deterioration prevalence increases with age and it is less frequent in individuals with higher studies Using MMSE and Set-Test we found several possible cases of cognitive deterioration in our population.