Background We aim to report a serie of odontogenic myxoma over a 40-year period. Material and Methods We conducted a retrospective and sectional review of OM cases. The clinical, radiographic and treatment data were collected from clinical records included cases whose medical records contained clinical, radiographic, histopathological, follow-up data of at least six months. Results There was a mild preference for the male with a mean age of 22.8 years. Seventy-seven percent of the lesions occurred in the posterior region of the mandible, presenting a multilocular radiolucent aspect (54%) with one presenting symptomatology. Conservative treatment was performed in all patients initially and recurrence was observed in two cases. Conclusions Odontogenic myxoma has a well-defined clinical profile and the choice of treatment should consider aspects such as patient’s age, lesion size, and location. Key words: Myxoma, odontogenic tumors, diagnosis, treatment.